Type 2 diabetes mellitus, particularly with autonomic neuropathy, is associated with a higher prevalence of gallbladder dysfunction and disease detectable by ultrasound.
Associated gallbladder dysfunction in type 2 diabetes with neuropathy warrants further study; leaves open implications for screening or outcomes.
Diabetic autonomic neuropathy gives rise to varied manifestations in the gastrointestinal tract i.e. gastropathies, nocturnal diarrhoea, oesophageal dysmotility, constipation and gallbladder dysfunction, being consequence of vagal neuropathy leading to reduced G.I. Motility. Gallbladder involvement in diabetic autonomic neuropathy is in the form of high incidence of gall bladder stones and a significant increase in gall bladder volume with poor concentration and poor visualization, with lack of symptoms of gallbladder disease. The present study concluded that gall bladder disease is more prevalent among type 2 diabetics. Diabetics with autonomic neuropathy tend to have larger gall bladders with poor contraction in response to fatty meals (due to vagal neuropathy), thus predisposing these patients to various forms of gall bladder disease.
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Singh et al. (2006) studied this question.
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