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August 5, 2026Journal of Peptide ScienceOpen Access

Gold Nanoparticles Coated With the Antimicrobial Peptide Os‐C(W5): Anticandidal and Biological Activity

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Authors

PPP. J. PalmRCR. R. ChiromboCCC. K. Chiramba

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Overview

Randomized trial demonstrates increased antifungal stability in fungal pathogens with GNP@Os‐C(W5), suggesting potential therapeutic applications.

Key Points

  • The aim is to evaluate the antimicrobial properties of Os‐C(W5) when conjugated to gold nanoparticles.
  • Generated gold nanoparticles (GNPs) coated with Os‐C(W5) using a modified tryptophan tagging method.
  • Assessed antifungal activity against planktonic Candida albicans and biofilm formation abilities.
  • Evaluated cytotoxic effects on HaCat cells and resistance to proteolytic degradation.
  • GNP@Os‐C(W5) displayed maintained antibiofilm activity with decreased biofilm biomass, reducing surface density compared to untreated controls.
  • Induced ultrastructural changes in Candida albicans, including irregular surfaces and cell lysis signs.
  • While GNP conjugation improved peptide stability, it compromised antioxidant properties and loss of nitric oxide scavenging activity.

Cite This Study

Palm et al. (2026) studied this question.

synapsesocial.com/papers/6a72e7d2226790f3706570cahttps://doi.org/10.1002/psc.70117
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