Key result
Autologous pericardial mitral reconstruction provides short-term function but fails from early fatal infection.
Why the study?
In small-breed dogs, appropriately sized prosthetic mitral valves are lacking, and complete surgical mitral valve reconstruction had not been reported.
Case Report (n=1)
No
Complete mitral valve reconstruction using fresh autologous pericardium is technically feasible and provides short-term mechanical function in a small-breed dog, though infection control remains the primary determinant of survival in infective endocarditis.
Supports technical feasibility of autologous pericardial mitral reconstruction in dogs; hypothesis-generating and should not change practice pending further evidence.
In humans, surgical repair is commonly performed for infective endocarditis (IE) associated with mitral valve destruction. However, extensive valve destruction may make repair impossible and require prosthetic valve replacement. In small-breed dogs, appropriately sized prosthetic valves are lacking, and complete surgical mitral valve reconstruction in dogs has not been reported. We encountered a Chihuahua that developed IE after mitral valve repair. During reoperation for progressive mitral regurgitation recurrence, the mitral leaflets were extensively destroyed and torn, and re-repair using native tissue was impossible; the entire valve was therefore reconstructed with fresh autologous pericardium. A graft was harvested and fashioned into a cylindrical valve based on a design previously described in a human study. Intraoperative saline testing and immediate postoperative echocardiography confirmed adequate opening and closure of the reconstructed pericardial valve, with only mild mitral regurgitation and no stenosis. The dog died on the second day after reoperative day of an uncontrolled infection caused by extended-spectrum beta-lactamase-producing Escherichia coli. This case demonstrates that an autologous pericardial valve can provide short-term mechanical function as a mitral valve in a small-breed dog and indicates that infection control is the principal determinant of outcome.
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Isayama et al. (2026) conducted a case report in Infective endocarditis with mitral valve destruction (n=1). Complete mitral valve reconstruction using fresh autologous pericardium was evaluated on Valve function and survival. Complete mitral valve reconstruction using fresh autologous pericardium provided adequate short-term mechanical function, but the dog died on postoperative day 2 from uncontrolled infection.
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