Key result
Mitral valve repair in dogs with severe mitral regurgitation resulted in a 66.7% surgical survival rate, with congestive heart failure resolving in 50% of the dogs.
Why the study?
Does mitral valve repair improve survival and resolve congestive heart failure in dogs with severe mitral regurgitation?
Observational (n=18)
Does mitral valve repair improve survival and resolve congestive heart failure in dogs with severe mitral regurgitation?
Mitral valve repair is feasible and may resolve congestive heart failure in dogs with severe naturally occurring mitral regurgitation, particularly those weighing >10 kg and treated within 6 months of CHF onset.
Supports feasibility of mitral valve repair in dogs; hypothesis-generating and requires controlled trials before clinical adoption.
OBJECTIVE: To describe surgical techniques for and assess outcome of treatment of mitral regurgitation in dogs. DESIGN: Uncontrolled prospective study. ANIMALS: 18 dogs with naturally occurring mitral regurgitation. PROCEDURE: All dogs weighed > 5 kg (11 lb) and had severe mitral regurgitation, congestive heart failure (CHF), and no serious noncardiac disease. Left ventricular volume indices, left atrial size, and degree of mitral regurgitation were determined echocardiographically before and after surgery. Repair techniques included circumferential annuloplasty, placement of artificial chordae, chordal fenestration and papillary muscle splitting, and edge-to-edge repair. Factors predictive for surgery survival and resolution of CHF were determined. RESULTS: 12 dogs survived surgery. Factors predictive for surgery survival included weight > 10 kg (22 lb) and CHF of less than 6 months' duration. In 9 dogs, CHF resolved for a median period of 1 year (range, 4 months to 3 years) after surgery. One dog had stable CHF at 12 months. One dog died as a result of progressive CHF; another was euthanatized for a noncardiac reason. Left ventricular diastolic volume index was 226.9 +/- 117.7 cm3/m2 before surgery and 134.9 +/- 70.4 cm3/m2 at 6 months after surgery (n = 10). Factors predictive for resolution of CHF included left ventricular diastolic volume index < 250 cm3/m2 and systolic volume index < 70 cm3/m2. CONCLUSION AND CLINICAL RELEVANCE: Mitral valve repair may resolve CHF in dogs with severe mitral regurgitation, particularly in dogs that weigh > 10 kg and are treated within 6 months of the onset of CHF.
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Griffiths et al. (2004) conducted an observational in Severe mitral regurgitation and congestive heart failure (n=18). Mitral valve repair was evaluated on Surgery survival. Mitral valve repair in dogs with severe mitral regurgitation resulted in a 66.7% surgical survival rate, with congestive heart failure resolving in 50% of the dogs.
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