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August 5, 2026Journal of Maxillofacial and Oral SurgeryOpen Access

Effectiveness of Intra-Socket Application of Dexamethasone- and Hyaluronic Acid-Soaked Gelfoam in Mandibular Third Molar Surgery

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Authors

VBVanshika BajpaiCAChithra AramanadkaSGSrikanth Gadicherla

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Overview

Randomized trial compares intra-socket dexamethasone and hyaluronic acid on postoperative outcomes, indicating dexamethasone's superior effect on mouth opening.

Key Points

  • This study aims to evaluate the effectiveness of dexamethasone and hyaluronic acid gelfoam in reducing postoperative complications after mandibular third molar extraction.
  • Prospective randomized controlled trial with 54 patients undergoing extraction of mandibular third molars.
  • Participants were divided into three groups: normal saline (control), dexamethasone, and hyaluronic acid gelfoam, with 18 in each group.
  • Evaluated facial swelling, mouth opening, and pain using Visual Analog Scale preoperatively and on postoperative days 3 and 7.
  • Mouth opening was significantly better in the dexamethasone group on day 3 (p = 0.021) and day 7 (p = 0.049).
  • Facial swelling showed no significant differences across groups on days 3 (p = 0.71) and 7 (p = 0.74).
  • Pain scores were generally lower in the dexamethasone and hyaluronic acid groups, but not statistically significant (p = 0.57, p = 0.82).

Cite This Study

Bajpai et al. (2026) studied this question.

synapsesocial.com/papers/6a72e7f4226790f37065748dhttps://doi.org/10.1007/s12663-026-03194-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intra-Alveolar Gelatin Sponge Delivery of Dexamethasone vs. Methylprednisolone After Mandibular Third-Molar Surgery: A Randomized Controlled Trial2026
  2. 2Efficacy of Dexamethasone on Pain and Swelling Following Extraction of Impacted Mandibular Third Molars2025
  3. 3Effect of intrasocket application of hyaluronic acid on pain, swelling, and trismus after surgical extraction of impacted mandibular third molar – A randomized control trial2026
  4. 4Effect of Dexamethasone Versus Triamcinolone Acetonide On Postoperative Complications After Impacted Third Molar Surgery2024
  5. 5Effect of submucosal administration of dexamethasone on postoperative discomfort after third molar surgery2024