Key result
Atosiban therapy is linked to acute non-cardiogenic pulmonary edema that rapidly resolves upon discontinuation.
Why the study?
Non-cardiogenic pulmonary edema is a rare complication of tocolysis, but its occurrence with atosiban remains poorly documented.
Does atosiban cause non-cardiogenic pulmonary edema in pregnant women treated for threatened preterm labor?
Case Report (n=1)
Does atosiban cause non-cardiogenic pulmonary edema in pregnant women treated for threatened preterm labor?
Atosiban therapy for preterm labor may rarely be associated with non-cardiogenic pulmonary edema, particularly in high-risk patients with multiple gestations and concomitant corticosteroid use.
Atosiban may trigger non-cardiogenic pulmonary edema; extends sparse reports but remains hypothesis-generating and should not change practice.
Non-cardiogenic pulmonary edema is a rare but potentially life-threatening complication of tocolytic therapy. While commonly associated with beta-agonists and calcium channel blockers, its occurrence with atosiban remains poorly documented. To date, only a small number of cases have been reported in the literature. We report the case of a 21-year-old primigravida with a dichorionic diamniotic twin pregnancy who developed acute hypoxemic respiratory failure during atosiban therapy for threatened preterm labor. A comprehensive diagnostic workup excluded cardiogenic, thromboembolic, and infectious causes. Imaging findings were consistent with pulmonary edema. Rapid clinical improvement following discontinuation of atosiban strongly supported a drug-related etiology. This case highlights a rare but clinically relevant adverse effect of atosiban and emphasizes the importance of early recognition, particularly in high-risk patients.
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Maigre et al. (2026) conducted a case report in Threatened preterm labor (n=1). Atosiban was evaluated. Atosiban therapy for threatened preterm labor in a twin pregnancy was associated with the development of acute non-cardiogenic pulmonary edema that rapidly resolved upon discontinuation.
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