Optical Control over Affinity and Reactivity

Tom Bösking

doi:10.18452/38298

August 3, 2026Open Access

Optical Control over Affinity and Reactivity

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Key Points

The aim is to design light-sensitive molecular components for the control of chemical affinity and reactivity.
Introduced a concept using ring size manipulation in macrocyclic diarylethenes to create and release molecular tension.
Developed a light-controlled protein purification method using affinity chromatography with immobilized azobenzene derivatives.
Identified selective peptide sequences via phage display that bind to the trans-isomer through photoinduced isomerization.
Successfully demonstrated control over [3+2] cycloadditions and diene isomerizations by adjusting ring tension.
Achieved reversible binding and release of functionalized biomolecules using light activation.
Provided a promising alternative to traditional nickel-histidine-based IMAC technology with reduced toxicity.

Implication

Experimental investigation of light-driven control of chemical properties in functionalized biomolecules, suggesting a novel method for protein purification.

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Cite This Study

Tom Bösking (2026) studied this question.

synapsesocial.com/papers/6a72e841226790f370657fd9 https://doi.org/10.18452/38298

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Optical Control over Affinity and Reactivity

Key Points

Implication

Discussion

Cite This Study

Optical Control over Affinity and Reactivity

Key Points

Implication

Discussion

Cite This Study

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