What question did this study set out to answer?

This review aims to explore the dual role of UDP-glucuronosyltransferases in tumor drug resistance and their metabolic implications.

The Dual Role of Human UDP-Glucuronosyltransferase-Mediated Metabolism in Tumor Drug Resistance: Mechanisms and Prospects

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Review outlines UGT-mediated drug resistance mechanisms in tumors, suggesting strategies for intervention.

This review aims to explore the dual role of UDP-glucuronosyltransferases in tumor drug resistance and their metabolic implications.
Reviewed structural characteristics and classification of UDP-glucuronosyltransferases (UGTs).
Analyzed tissue distribution and regulation mechanisms of UGTs.
Discussed strategies for multidimensional intervention against tumor resistance.
UGTs can promote drug resistance through enhanced metabolic clearance of antitumor drugs.
UGTs may also inhibit drug resistance via metabolic activation mechanisms.
Clinical validation of UGT-targeting strategies faces significant challenges.

Wang et al. (2026) studied this question.

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