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August 5, 2026HereditasOpen Access

The prognostic value of miR-363-5p in colorectal cancer and its associated molecular mechanisms

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Randomized trial investigates the prognostic significance of mir-363-5p in colorectal cancer, highlighting its potential as a protective factor.

This study aims to explore the prognostic significance of mir-363-5p in colorectal cancer and its underlying mechanisms.
Collected 156 paired samples from colorectal cancer patients
Assessed mir-363-5p levels using RT-qPCR, KM curves, and multivariable Cox regression
Evaluated cellular effects via flow cytometry, CCK-8 assay, Transwell assay, and validated through dual-luciferase reporter assays
Lower expression of mir-363-5p in TNM stage III + IV patients compared to stage I + II
Patients with low mir-363-5p expression had shorter overall survival (HR, 2.1; 95% CI, 1.5-3.5; P=0.003)
miR-363-5p acts as a tumor suppressor by targeting MEIS3, inhibiting malignant cellular behaviors

Xue et al. (2026) studied this question.

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Randomized trial investigates the prognostic significance of mir-363-5p in colorectal cancer, highlighting its potential as a protective factor.