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August 1, 2026HereditasOpen Access

MicroRNA-345-3p expression inhibits colorectal cancer liver metastasis by targeting KHDRBS1 and TGF-β signaling pathway

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Authors

SFSong FanBinzhou UniversityJZJian ZhaoXinxiang Central HospitalSLSongjie LiuXinxiang Central Hospital

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Implication

Randomized trial investigates microRNA-345-3p's role in liver metastasis in colorectal cancer, suggesting new therapeutic insights.

Key Points

  • This study aims to explore the role of microRNA-345-3p in liver metastasis associated with colorectal cancer and identify its molecular mechanisms.
  • Collected serum specimens from 110 colorectal cancer patients and 90 healthy individuals.
  • Assessed miR-345-3p and KHDRBS1 expression using quantitative real-time PCR.
  • Performed in vitro cell experiments to evaluate the effects of miR-345-3p on cell growth and epithelial-mesenchymal transition.
  • Significant decrease in miR-345-3p expression noted in colorectal cancer patients with liver metastasis.
  • Low miR-345-3p levels correlated with advanced TNM stages and poorer prognosis.
  • Overexpression of miR-345-3p inhibited colorectal cancer cell growth and epithelial-mesenchymal transition.

Cite This Study

Fan et al. (2026) studied this question.

synapsesocial.com/papers/6a6d9892e258b358b3c6c09fhttps://doi.org/10.1186/s41065-026-00715-5
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