What question did this study set out to answer?

To investigate the postnatal structural remodeling of the arterial internal elastic lamina (IEL) and determine the influence of hemodynamic blood flow on fenestral morphology.

May 1, 1996Circulation Research

Developmental Remodeling of the Internal Elastic Lamina of Rabbit Arteries

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Why the study?

Does altering blood flow affect the size of fenestrae in the internal elastic lamina of rabbit arteries during development?

Population

Rabbit arteries from 3 to 23 weeks of age (n=10 for flow alteration experiment)

Comparison

Decreased common carotid blood flow by 70% or… vs Control artery

Design

Preclinical

Follow-up

5 weeks (from 10 to 15 weeks of age)

Authors

LWLisa C. Y. WongToronto Western Hospital BLB. Lowell LangilleWestern University

Discussion

Member takes

Implication

Flow modulates IEL fenestrae during rabbit arterial development; leaves open hemodynamic roles in human vascular remodeling.

Key Points

To investigate the postnatal structural remodeling of the arterial internal elastic lamina (IEL) and determine the influence of hemodynamic blood flow on fenestral morphology.
Evaluated IEL fenestral dimensions, counts, and spatial density in rabbit carotid, renal, iliac arteries, and abdominal aorta from 3 to 23 weeks of age.
Modulated carotid blood flow at 10 weeks of age by ligating the ipsilateral external carotid artery (70% flow reduction, n=5) or contralateral common carotid artery (~2-fold flow increase, n=5), assessing arterial morphology at 15 weeks.
Carotid IEL fenestra area expanded from 11.3 ± 0.7 μm² at 3 weeks to 61.2 ± 5.5 μm² in adults, with total fenestrae increasing from 2.68 × 10⁵ to 9.27 × 10⁵ despite a 26% decrease in fenestral density per mm²; iliac artery fenestral density decreased by 70%.
Elevated blood flow increased fenestral area by 39% compared with controls, whereas a 70% decrease in blood flow resulted in 53.5% smaller fenestrae (P < .05).

Structured PICO

Does altering blood flow affect the size of fenestrae in the internal elastic lamina of rabbit arteries during development?

Population

Rabbit arteries from 3 to 23 weeks of age (n=10 for flow alteration experiment)

Intervention

Decreased common carotid blood flow by 70% (ipsilateral external carotid artery ligation) or doubled blood flow (contralateral common carotid ligation) at 10 weeks of age

Comparator

Control artery

Outcome

Size and number of fenestrae in the internal elastic laminasurrogate

Flow-dependent enlargement of fenestrae contributes to developmental remodeling of the internal elastic lamina in rabbit arteries.

Cite This Study

Wong et al. (1996) studied this question.

synapsesocial.com/papers/6a72ea80522bdff77a1cf342 https://doi.org/10.1161/01.res.78.5.799

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Developmental Remodeling of the Internal Elastic Lamina of Rabbit Arteries

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Developmental Remodeling of the Internal Elastic Lamina of Rabbit Arteries

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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