Why the study?
Cardiovascular manifestations of Marfan syndrome carry increased mortality, particularly in children, making early recognition critical to long-term management.
Highlights the presentation of severe infantile aortic root dilatation in siblings with classical Marfan syndrome, emphasizing the need for early recognition.
Severe infantile aortic dilatation in classical Marfan siblings supports early genetic screening; leaves optimal pediatric therapy open.
Cardiovascular manifestations of Marfan syndrome are associated with increased mortality, especially in the pediatric population. Early recognition is critical to long-term management. We present two cases of genetically defined "classical" Marfan syndrome presenting with severe infantile aortic root dilatation among siblings and discuss options for therapy.
No takes yet. Share an insight, caveat, or question.
Thomas et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: