Association of QRS Duration with Left Ventricular Structure and Function and Risk of Heart Failure in Middle-Aged and Older Adults: The Multi-Ethnic Study of Atherosclerosis (MESA)
Why the study?
Does QRS duration >100 ms predict incident heart failure and abnormal left ventricular structure/function in middle-aged and older adults without baseline cardiovascular disease?
Population
4,591 middle-aged and older adults without baseline cardiovascular disease from the Multi-Ethnic Study of…
Comparison
QRS duration >100 ms on baseline ECG vs QRS duration ≤100 ms (implied)
Design
Cohort
Follow-up
mean 7.1 years
Authors
Discussion
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Member takes
Implication
QRSd >100 ms may flag subclinical LV remodeling in asymptomatic adults; leaves open its independent value beyond imaging for HF prediction.
Structured PICO
Does QRS duration >100 ms predict incident heart failure and abnormal left ventricular structure/function in middle-aged and older adults without baseline cardiovascular disease?
P
Population
4,591 middle-aged and older adults without baseline cardiovascular disease from the Multi-Ethnic Study of Atherosclerosis (MESA), mean age 61 years, 51% women, 39% white.
I
Intervention
QRS duration >100 ms on baseline ECG
C
Comparator
QRS duration ≤100 ms (implied)
O
Outcome
Incident heart failure and measures of cardiac structure and function by cardiac MRIhard clinical
Prolonged QRS duration >100 ms on a baseline ECG is a useful marker of underlying left ventricular structural abnormalities that predispose asymptomatic adults to incident heart failure.
Cite This Study
Ilkhanoff et al. (2012) studied this question.