What question did this study set out to answer?

To investigate the molecular mechanisms by which pro-inflammatory Th1-conditioned cell transfer mediates axonal remodeling and functional motor recovery following spinal cord injury.

July 4, 2013Cell Death and DiseaseOpen Access

ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury

View Full Paper

Ask AI

Bookmark

Authors

HIHiroshi IshiiKanazawa University STShihori TanabeNational Institute of Occupational Safety and Health MUMasaki UenoNiigata University

Discussion

Member takes

Implication

Preclinical study demonstrates that interferon-γ drives therapeutic interleukin-10 secretion in injured spinal cords, indicating that controlled immune activation promotes motor recovery.

Key Points

To investigate the molecular mechanisms by which pro-inflammatory Th1-conditioned cell transfer mediates axonal remodeling and functional motor recovery following spinal cord injury.
Transferred Th1-conditioned cells from wild-type, interferon-γ knockout (ifn-γ-/-), or interleukin-10 knockout (il-10-/-) mice into murine spinal cord injury models.
Assessed microglial and macrophage activation alongside IL-10 expression, and administered intrathecal anti-IL-10 neutralizing antibodies to evaluate causal mechanisms.
Transferred Th1-conditioned cells robustly secreted IL-10 and activated spinal microglia and macrophages to upregulate IL-10 via an interferon-γ-dependent mechanism.
Spinal cord functional recovery was significantly attenuated when Th1 cells lacked interferon-γ or IL-10, as well as following direct intrathecal neutralization of IL-10.

Cite This Study

Ishii et al. (2013) studied this question.

synapsesocial.com/papers/6a72eb9dbfabfe3aef60d8bd https://doi.org/10.1038/cddis.2013.234

View Full Paper

Ask AI

Bookmark

Implication

Preclinical study demonstrates that interferon-γ drives therapeutic interleukin-10 secretion in injured spinal cords, indicating that controlled immune activation promotes motor recovery.

ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury

Discussion

Member takes

Implication

Key Points

Cite This Study

ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider