What question did this study set out to answer?

To determine whether adoptive transfer of distinct T-helper lymphocyte subsets promotes axonal regeneration and functional repair after contusion spinal cord injury.

August 9, 2012Cell Death and DiseaseOpen Access

Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury

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Authors

HIHiroshi IshiiKanazawa University XJXianhua JinJapan Science and Technology Agency MUMasaki UenoNiigata University

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Implication

Preclinical study reveals Th1-conditioned cell transfer restores locomotion and axonal regrowth in mice after spinal cord injury, indicating immunomodulatory therapy potential.

Key Points

To determine whether adoptive transfer of distinct T-helper lymphocyte subsets promotes axonal regeneration and functional repair after contusion spinal cord injury.
Administered Th1-, Th2-, or Th17-conditioned cells via intraperitoneal adoptive transfer into mice 4 days after contusion spinal cord injury.
Evaluated locomotor activity, sensory recovery, and histological regrowth of corticospinal and serotonergic axon tracts.
Assessed microglial/macrophage polarization, measured neurotrophin-3 secretion, and performed interleukin-10 neutralization assays.
Th1-conditioned cell transfer significantly improved locomotor and tactile recovery while promoting corticospinal and serotonergic fiber regrowth; Th2 and Th17 cells showed no therapeutic effect.
Th1 cell transfer activated spinal cord microglia and selectively upregulated the protective M2 microglia/macrophage subtype.
Th1 cells secreted higher levels of neurotrophin-3 than Th2 or Th17 cells, and antibody neutralization of Th1-derived interleukin-10 significantly blocked the observed functional and structural recovery.

Cite This Study

Ishii et al. (2012) studied this question.

synapsesocial.com/papers/6a956e97f127e75f5b82abfb https://doi.org/10.1038/cddis.2012.106

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Implication

Preclinical study reveals Th1-conditioned cell transfer restores locomotion and axonal regrowth in mice after spinal cord injury, indicating immunomodulatory therapy potential.

Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury

Discussion

Member takes

Implication

Key Points

Cite This Study

Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury

Discussion

Member takes

Implication

Key Points

Cite This Study

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