January 1, 1989The Japanese Journal of PharmacologyOpen Access

Comparison of the Effects of MCI-154, a New Cardiotonic Agent, and Some Ca2+-Sensitizing Agents on the Response of the Contractile System to Ca2+ in Skinned Cardiac Muscle

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Population

Chemically skinned fibers from guinea pig papillary muscles and isolated guinea pig papillary muscles

Comparison

MCI-154, sulmazole, pimobendan, and adibendan vs Comparison among the different agents

Design

Preclinical

Authors

YKYoshimi KitadaNobel Foundation MMMiyuki MoritaMitsubishi Group (Japan)ANAkihiro NarimatsuUniversity of Fukuchiyama

Discussion

Member takes

Implication

MCI-154 may inform Ca2+ sensitizer development in models; leaves open translation to human heart failure therapy.

Structured PICO

Population

Chemically skinned fibers from guinea pig papillary muscles and isolated guinea pig papillary muscles

Intervention

MCI-154, sulmazole, pimobendan, and adibendan (concentrations 10^-7 to 10^-4 M)

Comparator

Comparison among the different agents

Outcome

Ca2+-activated tension development, MgATP-activated tension development (rigor tension), and force of contractionsurrogate

MCI-154 is a potent cardiotonic agent that enhances Ca2+-activated tension and MgATP-activated tension in guinea pig papillary muscles, acting via a qualitatively different mechanism than other Ca2+-sensitizing agents.

Cite This Study

Kitada et al. (1989) studied this question.

synapsesocial.com/papers/6a72ed720df8cba8e260d8cf https://doi.org/10.1016/s0021-5198(19)42424-4

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Comparison of the Effects of MCI-154, a New Cardiotonic Agent, and Some Ca2+-Sensitizing Agents on the Response of the Contractile System to Ca2+ in Skinned Cardiac Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of the Effects of MCI-154, a New Cardiotonic Agent, and Some Ca2+-Sensitizing Agents on the Response of the Contractile System to Ca2+ in Skinned Cardiac Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider