Population
Dog cardiac myofibrils
Comparison
AR-L 115BS (100-300 micrometers) vs Absence of AR-L 115BS
Design
Preclinical
Authors
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Identifies troponin C as inotropic target in vitro; leaves open translation to intact myocardium or patients.
AR-L 115BS exerts positive inotropic effects by directly increasing the affinity of myofibrillar troponin C for calcium.
Solaro et al. (1982) studied this question.
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