Population
Animal models including anesthetized and unanesthetized dogs, pithed open-chest cats, guinea pig atria and…
Comparison
APP 201-533 [3-amino-6-methyl-5-phenyl-2-pyridino… vs Amrinone and ouabain
Design
Preclinical
Authors
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No immediate clinical implications from canine data; leaves open translation of Ca2+-sensitizing inotropes to human HF.
APP 201-533 is a novel positive inotropic agent that enhances cardiac contractility by inhibiting phosphodiesterase and increasing myocardial calcium sensitivity.
Salzmann et al. (1985) studied this question.
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