A newly developed high-Tc SQUID magnetometer system can successfully record clear magnetocardiogram signals in mice, providing a useful tool for preclinical biomagnetic monitoring.
Advances preclinical mouse MCG research; leaves clinical translation and human validation open.
We have developed a biomagnetic measurement system for mouse by using high-TCSQUID magnetometer. The system consists of a high-TCSQUID magnetometer, a table-top magnetically shielded box, and a nonmagnetic dewar with a warm-to-cool distance of about 4 mm. Mice with weights of about 27 g were anesthetized and fixed in supine position on a plastic xyz-stage inside the shield box. The SQUID readout signal was digitized in 24-bit and recorded with sampling rate of 1280 Hz. We carried out a scanning measurement by changing x- and y-position of the subject inside the shield box. Finally, we could obtain clear mouse MCG waveforms of about 20 pT in peak amplitude with well defined P-, QRS-, and T-wave. We demonstrated the high-TCSQUID magnetometer based biomagnetic measurement system is useful for monitoring mouse MCG signals with sufficient noise-to-signal ratio.
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Kim et al. (2010) studied this question.
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