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Objective To investigate the expression of cyclooxygenase-2 (COX-2) and E-cadherin( Ecad) in meningioma and the clinical significance. Methods The expressions of Ki-67, COX-2 and E-cad were detected in 60 cases of meningioma by immunohistochemistry method, and the expressions of COX-2 mRNA、EcadmRNA were examined by in situ hybridization. Results There was significant correlation between over-expression of Ki-67、 COX-2 and decreased expression of E-cad with pathologic grade and invasion ( P ＜ 0. 05 ).There was negative correlation between the expression of COX-2 and E-cad ( P ＜ 0. 05 ). Conclusion Expressions of COX-2 and E-cad were significant correlated to pathologic grade and invasion. They may exert mutual effect and co-regulate the invasive growth of meningiomas. Combined detection of COX-2 and E-cad may help to predict the prognosis of patients.
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Wang et al. (2010) studied this question.
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