Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 15, 1998Journal of Clinical InvestigationOpen Access

Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does persistent allopeptide reactivity and epitope spreading predict the development of coronary artery vasculopathy in heart allograft recipients?

Population

34 heart allograft recipients

Comparison

Persistent allopeptide reactivity and epitope… vs Patients who showed no alloreactivity after the…

Design

Cohort

Follow-up

up to 36 months

Authors

RCRodica CiubotariuColumbia University Irving Medical CenterZLZhi‐Gang LiuShenzhen UniversityACAdriana I. ColovaiMontefiore Medical Center

Discussion

Loading...

Member takes

Implication

Persistent alloreactivity may aid vasculopathy risk stratification post-heart transplant; leaves open whether targeting indirect allorecognition improves outcomes.

Structured PICO

Does persistent allopeptide reactivity and epitope spreading predict the development of coronary artery vasculopathy in heart allograft recipients?

P
Population
34 heart allograft recipients
I
Intervention
Persistent allopeptide reactivity and epitope spreading (assessed via T cell alloresponses to donor using synthetic peptides)
C
Comparator
Patients who showed no alloreactivity after the first 6 months after transplantation
O
Outcome
Incidence of coronary artery vasculopathy (CAV)hard clinical

Persistent allopeptide reactivity and epitope spreading are associated with the development of coronary artery vasculopathy, suggesting a role for the indirect allorecognition pathway in chronic heart allograft rejection.

Cite This Study

Ciubotariu et al. (1998) studied this question.

synapsesocial.com/papers/6a72f0b91a70e69bd7154d16https://doi.org/10.1172/jci1117
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Indirect recognition of donor HLA-DR peptides in organ allograft rejection.1996 · 244 citations
  2. 2Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.1987 · 302 citations
  3. 3Heterogeneity in antigen processing by different types of antigen-presenting cells. Effect of cell culture on antigen processing ability1992 · 84 citations