mdx mouse muscle exhibits altered calcium regulation and reduced strength, highlighting the need to measure both function and morphology in treatment trials.
Questions compensatory role of hypertrophy in mdx; leaves open human translation and supports dual functional-morphologic endpoints in trials.
We compared mdx and C57BL10 anterior tibial muscle force in situ (single pulse, multiple pulse, staircase, posttetanic potentiation, and fatiguing stimulation patterns) to define muscle strength, physiology, and fatigue resistance. The relatively hypertrophied mdx muscle showed: reduced strength (N/cm2), an increased twitch-tetanus ratio, and resistance to post-fatigue twitch slowing. These differences implicate altered mdx calcium regulation, and emphasize the importance of measuring both muscle function and morphology in mdx treatment trials.
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Quinlan et al. (1992) studied this question.
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