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December 20, 2013PLoS ONEOpen Access

Platelet Content of Nitric Oxide Synthase 3 Phosphorylated At Serine1177 Is Associated with the Functional Response of Platelets to Aspirin

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Why the study?

Is platelet responsiveness to aspirin associated with differences in nitric oxide generation and NOS3 phosphorylation in patients with stable coronary ischemia?

Population

50 patients with stable coronary ischemia, divided into ASA-sensitive and ASA-resistant based on PFA-100…

Comparison

Aspirin (ASA) sensitive platelets vs Aspirin (ASA) resistant platelets

Design

Cross-sectional

Authors

JMJavier ModregoInstituto de Investigación Sanitaria del Hospital Clínico San CarlosLALuís AzconaIcahn School of Medicine at Mount SinaiNMNaiara Martín‐Palacios

Discussion

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Implication

May link NOS3 phosphorylation to aspirin sensitivity in stable CAD; hypothesis-generating without practice implications.

Structured PICO

Is platelet responsiveness to aspirin associated with differences in nitric oxide generation and NOS3 phosphorylation in patients with stable coronary ischemia?

P
Population
50 patients with stable coronary ischemia, divided into ASA-sensitive (n=26) and ASA-resistant (n=24) based on PFA-100 testing.
I
Intervention
Aspirin (ASA) sensitive platelets
C
Comparator
Aspirin (ASA) resistant platelets
O
Outcome
Platelet content of phosphorylated NOS3 at Serine1177 and nitric oxide (NO) generationsurrogate

Aspirin responsiveness in patients with stable coronary ischemia is associated with increased platelet NOS3 phosphorylation at Serine1177 and enhanced nitric oxide release.

Cite This Study

Modrego et al. (2013) studied this question.

synapsesocial.com/papers/6a72f799bfabfe3aef60dcb0https://doi.org/10.1371/journal.pone.0082574
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased Platelet Sensitivity to Collagen in Individuals Resistant to Low-Dose Aspirin2000 · 135 citations
  2. 2Further Evidence of the Presence of Constitutive and Inducible Nitric Oxide Synthase Isoforms in Human Platelets1996 · 100 citations
  3. 3cGMP-Mediated Negative-Feedback Regulation of Endothelial Nitric Oxide Synthase Expression by Nitric Oxide1999 · 106 citations
  4. 4Nitric oxide released from activated platelets inhibits platelet recruitment.1997 · 392 citations
  5. 5Proteomic changes related to “bewildered” circulating platelets in the acute coronary syndrome2011 · 47 citations