Key result
Aspirin-resistant platelets from coronary ischemic patients showed increased expression of glyceraldehyde 3-phosphate dehydrogenase compared to aspirin-sensitive platelets (4273.3 vs 1751.1; P=0.001).
Why the study?
Are there differences in the protein expression profile of platelets between aspirin-resistant and aspirin-sensitive coronary ischemic patients?
Observational (n=51)
Are there differences in the protein expression profile of platelets between aspirin-resistant and aspirin-sensitive coronary ischemic patients?
Absolute Event Rate: 4273.3% vs 1751.1%
p-value: p=0.001
Aspirin-resistant and aspirin-sensitive platelets exhibit different protein expression profiles related to energetic metabolism, cytoskeleton, oxidative stress, and cell survival, which may explain their differential response to aspirin.
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May identify metabolic targets in aspirin resistance; hypothesis-generating and should not yet alter antiplatelet practice.
Carlos et al. (2009) conducted an observational in Coronary ischaemia (n=51). Aspirin resistance vs. Aspirin sensitivity was evaluated on Expression of glyceraldehyde 3-phosphate dehydrogenase (95% CI 1815.11-4061.2, p=0.001). Aspirin-resistant platelets from coronary ischemic patients showed increased expression of glyceraldehyde 3-phosphate dehydrogenase compared to aspirin-sensitive platelets (4273.3 vs 1751.1; P=0.001).
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