Key result
Aspirin-sensitive platelets showed higher caspase-3 activity (1.91-fold; P<0.05) and cytochrome C levels (1.84-fold; P<0.05) upon stimulation compared to aspirin-resistant platelets.
Why the study?
Inadequate platelet response to aspirin occurs in some patients under chronic treatment, prompting investigation into whether aspirin-sensitive and aspirin-resistant platelets differ in apoptotic capability.
Do aspirin-sensitive and aspirin-resistant platelets have differences in their apoptotic capability in clinically stable ischemic coronary patients?
Cross-Sectional (n=24)
Do aspirin-sensitive and aspirin-resistant platelets have differences in their apoptotic capability in clinically stable ischemic coronary patients?
Effect estimate: 1.91-fold higher
p-value: p=<0.05
Aspirin-sensitive platelets exhibit a greater capacity for apoptosis during robust activation compared to aspirin-resistant platelets, suggesting a potential cellular mechanism underlying aspirin resistance.
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Highlights apoptotic differences by aspirin sensitivity; hypothesis-generating and should not yet change practice.
Zamorano‐León et al. (2020) conducted a cross-sectional in Ischemic coronary disease (n=24). Aspirin sensitivity vs. Aspirin resistance was evaluated on Caspase-3 activity after stimulation with calcium ionophore (1.91-fold higher, p=<0.05). Aspirin-sensitive platelets showed higher caspase-3 activity (1.91-fold; P<0.05) and cytochrome C levels (1.84-fold; P<0.05) upon stimulation compared to aspirin-resistant platelets.
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