Key result
Haplotypes of seven candidate genes were not associated with aspirin non-responsiveness (24.6%), which instead correlated with increased platelet counts (p=0.03) and vWF levels (p<0.001).
Why the study?
Are haplotypes of seven candidate genes associated with aspirin responsiveness in patients with symptomatic vascular disease?
Observational (n=463)
Are haplotypes of seven candidate genes associated with aspirin responsiveness in patients with symptomatic vascular disease?
Aspirin non-responsiveness in patients with symptomatic vascular disease is not explained by common haplotypes in seven key platelet function genes, but is associated with higher platelet counts and von Willebrand Factor levels.
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Aspirin non-responsiveness correlates with platelet count and vWF, not candidate gene haplotypes; hypothesis-generating for alternative mechanisms in vascular disease.
Williams et al. (2008) conducted an observational in Symptomatic vascular disease (stroke, transient ischemic attack, or acute coronary disease) (n=463). Seven candidate gene haplotypes (ITGA2, ITGA2B, ITGB3, GPIBA, GP6, P2RY1, PTGS1) was evaluated on Aspirin non-responsiveness (failure to prolong PFA-100 CEPI-CT). Haplotypes of seven candidate genes were not associated with aspirin non-responsiveness (24.6%), which instead correlated with increased platelet counts (p=0.03) and vWF levels (p<0.001).
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