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January 1, 2008Cerebrovascular Diseases

Aspirin Responsiveness in Acute Brain Ischaemia: Association with Stroke Severity and Clinical Outcome

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Why the study?

Does impaired aspirin responsiveness worsen stroke severity and clinical outcomes in patients with acute brain ischaemia?

Population

105 patients with acute brain ischaemia treated with aspirin since hospital admission, mean age 63 +/- 12…

Comparison

Impaired aspirin responsiveness assessed by… vs Good aspirin responsiveness

Design

Cohort

Authors

YSYvonne SchwammenthalTel Aviv UniversityRTRakefet TsabariSheba Medical CenterБШБ. С. ШенкманInstitute of Biomedical Problems

Discussion

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Implication

Impaired aspirin responsiveness flags higher-risk acute ischaemia patients; hypothesis-generating for testing or alternative strategies before practice change.

Structured PICO

Does impaired aspirin responsiveness worsen stroke severity and clinical outcomes in patients with acute brain ischaemia?

P
Population
105 patients with acute brain ischaemia treated with aspirin since hospital admission, mean age 63 +/- 12 years, 66% men.
I
Intervention
Impaired aspirin (ASA) responsiveness (partial response or complete unresponsiveness) assessed by optical aggregometry and Impact-R
C
Comparator
Good aspirin responsiveness
O
Outcome
Stroke severity at baseline, early clinical improvement, and functional outcome during follow-uphard clinical

Impaired aspirin responsiveness in acute brain ischaemia is associated with worse neurological deficits, early clinical deterioration, and poorer functional outcomes.

Limitations

  • Requires further evaluation in larger longitudinal studies

Cite This Study

Schwammenthal et al. (2008) studied this question.

synapsesocial.com/papers/6a7bf9c18add427333df796chttps://doi.org/10.1159/000118382

Topics

Dual antiplatelet therapy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation.1998 · 242 citations
  2. 2Aspirin response and failure in cerebral infarction.1993 · 227 citations
  3. 3A new point-of-care method for monitoring anti-platelet therapy: Application of the cone and plate(let) analyzer2005 · 34 citations
  4. 4Previous Use of Aspirin and Baseline Stroke Severity2006 · 40 citations
  5. 5Functional and Biochemical Evaluation of Platelet Aspirin Resistance After Coronary Artery Bypass Surgery2003 · 288 citations