Why the study?
Does aspirin resistance alter the platelet proteome in healthy subjects and patients with coronary artery disease?
Population
93 healthy subjects and a separate cohort of 17 patients with stable coronary artery disease on long term…
Comparison
Aspirin 300 mg daily for 28 days; long-term… vs Baseline and aspirin-sensitive subjects
Design
Cohort
Follow-up
28 days
Authors
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Aspirin resistance should not alter therapy yet; leaves open glycoprotein IIIa expression as a hypothesis-generating biomarker for resistance.
Does aspirin resistance alter the platelet proteome in healthy subjects and patients with coronary artery disease?
Aspirin resistance is associated with increased platelet glycoprotein IIIa expression, providing a potential novel biomarker for identifying resistant patients.
Floyd et al. (2014) studied this question.
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