Key result
Three vitamin D binding protein isotypes were increased in ASA-resistant coronary ischemic patients compared to ASA-sensitive patients.
Population
38 coronary ischemic patients, plus blood from healthy volunteers for in vitro analysis.
Design
Case-control
Authors
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May identify aspirin-resistant coronary ischemia; hypothesis-generating for vitamin D binding protein as regulator, requiring prospective validation.
Case-Control (n=38)
Vitamin D binding protein is elevated in aspirin-resistant coronary ischemic patients and may act as a novel regulator blunting the inhibitory effect of aspirin on platelets.
López‐Farré et al. (2007) conducted a case-control in Coronary ischemia (n=38). ASA resistance vs. ASA sensitivity was evaluated on Plasma proteome expression (fibrinogen gamma chain, haptoglobin, vitamin D binding protein). Three vitamin D binding protein isotypes were increased in ASA-resistant coronary ischemic patients compared to ASA-sensitive patients.
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