January 1, 1996Journal of Cardiovascular Pharmacology

Further Evidence of the Presence of Constitutive and Inducible Nitric Oxide Synthase Isoforms in Human Platelets

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Population

Human platelets

Comparison

Lipopolysaccharide plus interferon-gamma… vs Resting platelets

Design

Preclinical

Authors

LCLiuh‐Yow ChenInstitute of Molecular Biology, Academia Sinica JMJ. L. MehtaUniversity of California, San Francisco

Discussion

Member takes

Implication

Hypothesis-generating for iNOS in platelet inflammation; leaves open any clinical role pending human validation.

Structured PICO

Population

Human platelets

Intervention

Lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma) stimulation

Comparator

Resting platelets

Outcome

Presence and expression of endothelial constitutive NOS (ecNOS) and inducible NOS (iNOS) isoforms and their mRNAsurrogate

This study provides definitive evidence that human platelets possess both ecNOS and iNOS isoforms, with iNOS expression being inducible by LPS and IFN-gamma.

Cite This Study

Chen et al. (1996) studied this question.

synapsesocial.com/papers/6a72f79ebfabfe3aef60dcbc https://doi.org/10.1097/00005344-199601000-00024

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Further Evidence of the Presence of Constitutive and Inducible Nitric Oxide Synthase Isoforms in Human Platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Further Evidence of the Presence of Constitutive and Inducible Nitric Oxide Synthase Isoforms in Human Platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider