Small differences in Drosophila tropomyosin expression significantly impact muscle function and ultrastructure, with sarcomere length being a key determinant of flight muscle function.
Drosophila tropomyosin model suggests sarcomere length influences muscle function; leaves open relevance to human cardiac myopathies.
The effects of promoter deletions on Drosophila tropomyosin I (TmI) gene expression have been determined by measuring TmI RNA levels in transformed flies. Decreases in RNA levels have been correlated with rescue of flightless and jumpless mutant phenotypes in Ifm(3)3 mutant transformed flies and changes in muscle ultrastructure. The results of this analysis have allowed us to identify a region responsible for 20% of maximal TmI expression, estimate threshold levels of TmI RNA required for indirect flight and jump muscle function, and obtain evidence suggesting that sarcomere length may be an important determinant of flight muscle function.
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Tansey et al. (1991) studied this question.
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