Population
Mice with conditional Mttp deletion in villus enterocytes generated using a tamoxifen-inducible…
Design
Preclinical
Authors
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Intestinal Mttp inhibition may fail to suppress circulating lipids via hepatic compensation; leaves open its utility as a lipid-lowering strategy.
Intestine-specific Mttp deletion in mice severely impairs intestinal triglyceride secretion but triggers a compensatory induction of hepatic lipogenesis and VLDL secretion.
Xie et al. (2005) studied this question.
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