May 1, 1998AJP Cell Physiology

Equibiaxial strain and strain rate stimulate early activation of G proteins in cardiac fibroblasts

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Structured PICO

Population

Rat cardiac fibroblasts

Intervention

Equibiaxial strain at higher rates (e.g., 1.2%/s via 12 cycles of 3% strain or 6 cycles of 6% strain over 60 s, or a single 6% cycle over 10 s)

Comparator

Lower strain rates (e.g., 0.6%/s or 0.2%/s)

Outcome

G protein activation (AAGTP binding to G alpha q and G alpha i1)surrogate

The rate of mechanical strain application modulates early G protein activation in cardiac fibroblasts, highlighting a mechanism for mechanotransduction in cardiac remodeling.

Authors

SGSiva R. P. GudiHirosaki University ALAnn A. LeeAdvanced Tissue (United States)CCCraig B. ClarkFurman University

Discussion

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Implication

Animal data preclude practice change; leaves open strain-rate G protein signaling as a remodeling mechanism.

Cite This Study

Gudi et al. (1998) studied this question.

synapsesocial.com/papers/6a72fc7f64272606b331e37a https://doi.org/10.1152/ajpcell.1998.274.5.c1424

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