Key result
Treatment with a miR-10a-5p mimic suppressed pro-inflammatory responses, promoted therapeutic adipogenesis, and improved systemic glucose tolerance in vivo.
Why the study?
This study investigated the role of microRNAs generated from adipose tissue macrophages during adipose tissue remodeling induced by pharmacological and nutritional stimuli.
Macrophage-generated miR-10a-5p reduces adipose tissue inflammation and promotes therapeutic adipogenesis, suggesting a potential target for metabolic disorders.
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Hypothesis-generating for miR-10a-5p mimics in metabolic disease; human trials required before clinical consideration.
Cho et al. (2019) studied Adipose tissue remodeling and inflammation. miR-10a-5p mimic and CL316,243 treatment vs. Wild type or untreated controls was evaluated on Adipose tissue remodeling, pro-inflammatory gene expression, and beige adipogenesis. Treatment with a miR-10a-5p mimic suppressed pro-inflammatory responses, promoted therapeutic adipogenesis, and improved systemic glucose tolerance in vivo.
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