Key result
Four patients who developed Kawasaki disease in infancy experienced severe long-term coronary complications including aneurysms and stenoses, requiring continuous cardiovascular monitoring into adulthood.
Case Report (n=4)
No
This case series highlights the severe, long-term coronary complications of Kawasaki disease and emphasizes the necessity of lifelong cardiovascular monitoring for these patients.
Suggests lifelong monitoring for infantile Kawasaki disease survivors; hypothesis-generating from case data, prospective studies needed.
The long-term sequelae of KD represent a consequence of the inflammatory damage which occur in the acute phase, particularly involving the coronary arteries. The possible vascular complications include coronary artery aneurysms (CAAs), thrombosis or stenosis, which then can lead to acute myocardial infarction or chronic ischemic disease. About 25% of untreated KDs complicate with CAAs [1], and up to 5% of those treated with IVIGs [2].
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Zagarese et al. (2022) conducted a case report in Kawasaki Disease with Coronary Artery Disease (n=4). Kawasaki disease was evaluated. Four patients who developed Kawasaki disease in infancy experienced severe long-term coronary complications including aneurysms and stenoses, requiring continuous cardiovascular monitoring into adulthood.
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