April 1, 2019Journal of Applied Pharmaceutical ScienceOpen Access

Camellia sinensis and epicatechin abate doxorubicin-induced hepatotoxicity in male Wistar rats via their modulatory effects on oxidative stress, inflammation, and apoptosis

Q: What is the clinical evidence from this study?

Study design: Other. Population: Doxorubicin-induced hepatotoxicity (n=40). Intervention: Camellia sinensis aqueous extract and epicatechin vs. Doxorubicin alone. Primary outcome: Serum alanine transaminase (ALT) activity (-46.02% change, p=<0.05).

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Key result

Camellia sinensis aqueous extract and epicatechin significantly reduced doxorubicin-induced hepatotoxicity in male Wistar rats, decreasing elevated serum ALT activity by 46% and 43% respectively (p < 0.05).

Why the study?

This study aimed to evaluate the preventive effects and potential mechanisms of Camellia sinensis leaf aqueous extract and epicatechin in doxorubicin-induced liver injury.

Does Camellia sinensis aqueous extract or epicatechin prevent doxorubicin-induced hepatotoxicity in male Wistar rats?

Population

Male Wistar rats injected with doxorubicin

Comparison

C. sinensis aqueous extract vs epicatechin in Dox-injected rats

Design

Preclinical animal study

Follow-up

6 weeks

Authors

OAOsama M. AhmedBeni-Suef University MAManal Abdul‐HamidBeni-Suef University AEAhlam M. El-BakryBeni-Suef University

Discussion

Member takes

Implication

Hypothesis-generating for Camellia sinensis in doxorubicin hepatotoxicity; human trials needed before clinical consideration.

Structured PICO

Does Camellia sinensis aqueous extract or epicatechin prevent doxorubicin-induced hepatotoxicity in male Wistar rats?

Population

40 male Wistar rats, aged 8-10 weeks, with doxorubicin-induced hepatotoxicity, treated and followed for 6 weeks.

Intervention

Camellia sinensis (green tea) aqueous extract (200 mg/kg) or epicatechin (25 mg/kg) administered orally every other day for 6 weeks, alongside doxorubicin.

Comparator

Doxorubicin alone (4 mg/kg/week intraperitoneally) plus vehicle (1% CMC solution orally every other day) for 6 weeks.

Outcome

Amelioration of doxorubicin-induced liver injury measured by serum albumin, alpha-fetoprotein, total bilirubin, ALT, AST, ALP, GGT, TNF-alpha, IL-4, and liver oxidative stress/apoptosis markers at 6 weeks.surrogate

Main Result

Effect estimate: -46.02% change

Absolute Event Rate: 30.86% vs 57.17%

p-value: p=<0.05

Camellia sinensis aqueous extract and epicatechin demonstrate chemopreventive potential against doxorubicin-induced hepatotoxicity in rats by reducing oxidative stress, inflammation, and apoptosis.

Cite This Study

Ahmed et al. (2019) studied Doxorubicin-induced hepatotoxicity (n=40). Camellia sinensis aqueous extract and epicatechin vs. Doxorubicin alone was evaluated on Serum alanine transaminase (ALT) activity (-46.02% change, p=<0.05). Camellia sinensis aqueous extract and epicatechin significantly reduced doxorubicin-induced hepatotoxicity in male Wistar rats, decreasing elevated serum ALT activity by 46% and 43% respectively (p < 0.05).

synapsesocial.com/papers/6a72ff2f91c366bb2031e321 https://doi.org/10.7324/japs.2019.90405

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Camellia sinensis and epicatechin abate doxorubicin-induced hepatotoxicity in male Wistar rats via their modulatory effects on oxidative stress, inflammation, and apoptosis

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Camellia sinensis and epicatechin abate doxorubicin-induced hepatotoxicity in male Wistar rats via their modulatory effects on oxidative stress, inflammation, and apoptosis

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

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