Key result
Injection of the selective ACE2 inhibitor MLN4760 into the nucleus of the solitary tract attenuated baroreceptor reflex sensitivity for reflex bradycardia from 1.16 to 0.33 ms mmHg-1 (P<0.05).
Population
Sprague-Dawley rats (n=8 for the MLN4760 experiment)
Comparison
Injection of selective ACE2 inhibitor MLN4760… vs Baseline (before injection)
Design
Preclinical
Follow-up
30-60 min
Authors
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NTS ACE2 supports baroreflex bradycardia in rats; leaves open translation to human autonomic control or disease.
Absolute Event Rate: 0.33% vs 1.16%
p-value: p=<0.05
Local synthesis of Ang(1-7) from Ang II by ACE2 within the NTS is required for normal baroreflex control of heart rate in rats.
Diz et al. (2008) studied this question. MLN4760 vs. Before injection was evaluated on Baroreceptor reflex sensitivity for reflex bradycardia (p=<0.05). Injection of the selective ACE2 inhibitor MLN4760 into the nucleus of the solitary tract attenuated baroreceptor reflex sensitivity for reflex bradycardia from 1.16 to 0.33 ms mmHg-1 (P<0.05).
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