Key result
Visceral fat reduction was significantly associated with improvements in systolic (β = 0.234) and diastolic (β = 0.237) blood pressure in overweight or obese males, but not in females.
Why the study?
Visceral adiposity plays a key role in hypertension, but the relationship between visceral fat reduction and blood pressure changes in overweight or obese Chinese individuals required evaluation.
Does visceral fat reduction improve systolic and diastolic blood pressure in overweight or obese adults?
Observational (n=168)
No
Does visceral fat reduction improve systolic and diastolic blood pressure in overweight or obese adults?
Effect estimate: β = 0.234 (95% CI 0.103, 0.365)
p-value: p=0.001
Visceral fat reduction is positively associated with improvements in systolic and diastolic blood pressure in overweight or obese men, but not women, highlighting a potential sex-specific response to weight loss interventions.
Suggests sex-specific BP responses to visceral fat loss; hypothesis-generating and requires prospective trials before clinical consideration.
Visceral adiposity has been reported to play a key role in hypertension compared with other measurements of regional or general obesity. The aim of current study was to evaluate the relationship between visceral fat reduction and changes in blood pressure in a group of overweight or obese Chinese individuals. An observational study was conducted with 168 participants (ChiCTR-OOC-17012000). Body composition, blood parameters and blood pressure were assessed at the beginning and end of the intervention. Males and females were categorized separately into quartiles according to changes in visceral fat during the intervention. Multiple linear regression models were used to assess the associations of changes in systolic and diastolic blood pressure with changes of visceral fat area, adjusted for potential confounders. Changes in visceral fat was significantly associated with systolic and diastolic blood pressure in men for systolic (β = 0.234, 95% CI: 0.103, 0.365; p = 0.001) and diastolic blood pressure (β = 0.237; 95% CI: 0.127, 0.346; p <0.001), but not in women after adjustment for the same potential confounders for systolic blood (β = − 0.003, 95% CI: − 0.260, 0.255; p = 0.984) and diastolic blood pressure (β = 0.101, 95% CI: − 0.072, 0.273; p = 0.249). A positive association was observed between reduction in visceral fat and improvements in both systolic blood and diastolic blood pressures in males but not females in a 12-week meal replacement intervention. The Ethics Committee of Peking University Health Science Center approved the study protocol on 6 July 2017. The authors confirm that all ongoing and related trials for this intervention were carried out following the rules of the Declaration of Helsinki of 1975 and registered (ChiCTR-OOC-17012000). http://www.chictr.org.cn/showprojen.aspx?proj=20426
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Guo et al. (2019) conducted an observational in Overweight or obesity (n=168). Visceral fat reduction was evaluated on Association of changes in visceral fat area with changes in systolic blood pressure in males (β = 0.234, 95% CI 0.103, 0.365, p=0.001). Visceral fat reduction was significantly associated with improvements in systolic (β = 0.234) and diastolic (β = 0.237) blood pressure in overweight or obese males, but not in females.
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