2626-P: Impact of Visceral Fat Reduction on Cardiometabolic Parameters in Adults with Diabetes Enrolled in a 12-Week Intensive Lifestyle Intervention Program

Introduction and Objective: Visceral adiposity increases cardiometabolic risk in diabetes. The extent to which reductions in visceral fat (VF) influence cardiometabolic parameters after lifestyle intervention, and whether gender differences exist, remains unclear. Methods: We conducted a retrospective cohort study of 137 adults with diabetes who completed a 12-week multidisciplinary intensive lifestyle intervention (ILI). Participants were 64% female, mean age 52.9 ± 11.8 years, 84% had type 2 diabetes, diabetes duration 10 ± 9.3 years, weight 109 ± 58 kg and BMI 36.7 ± 5.1 kg/m². The evaluated cardiometabolic parameters included A1C, BP, lipid profile, CRP, liver enzymes, and kidney function. VF was assessed using bioelectrical impedance. Results: Pairwise Pearson correlation analyses showed that VF reduction correlated with improvements in total cholesterol (r = 0.21, p = 0.016) and LDL cholesterol (r = 0.18, p = 0.048). No other cardiometabolic changes were seen with VF reduction. Linear regression analyses adjusted for sex showed that females achieved less reductions in VF (β = 0.72 kg, 95% CI 0.18 to 1.26. p = 0.01), total cholesterol (β = 12.2 mg/dL, 95% CI 0.2 to 24.0, p = 0.046), and triglycerides (β = 52.2 mg/dL, 95% CI 10.4 to 93.9, p = 0.015) compared to males. Conclusion: These findings indicate that after a 12-week of ILI, reduction in VF is only associated with improvements in lipid profile. These improvements are significantly lower in women compared to men. Disclosure M. Al-Badri: None. F. Trabzounly: None. M. Fallaha: None. J. Jacob: None. O. Hamdy: Research Support; Current; Novo Nordisk. Consultant; Current; Abbott. Research Support; Current; Eli Lilly and Company. A. Mottalib: Consultant; Current; American Diabetes Association.