2625-P: Gender-Specific Differences in Body Composition and Cardiometabolic Risk Factors in Response to Intensive Lifestyle Intervention in Type 2 Diabetes

Introduction and Objective: Intensive lifestyle intervention (ILI) improves glycemic control, body composition parameters, and other cardiometabolic risk factors in patients with type 2 diabetes; however, gender differences remain unclear. This study examined gender differences in body composition and cardiometabolic risk factors in response to ILI. Methods: We conducted a retrospective cohort study of 115 adults with type 2 diabetes (64% women) who completed a 12-week of multidisciplinary ILI. Participants had a mean age of 54.9 ± 10.5 years, diabetes duration of 7.8 ± 5.9 years, and baseline weight of 111.5 ± 62.4 kg, and BMI of 37.2 ± 5.1 kg/m². Body composition and visceral fat (VF) were evaluated by bioelectrical impedance technique. Results: Compared to women, men had significant reduction in percentage body fat (−4.2 ± 4.2% vs −1.9 ± 3.2%; p = 0.001), visceral fat level (−1.35 ± 1.68 vs −0.57 ± 1.32 kg; p = 0.007), and triglycerides (−82.6 ± 151.9 vs −19.8 ± 50.3 mg/dL; p = 0.0017). No differences were seen in percentage weight loss, or changes in BMI, A1C, lipid profile, blood pressure, C-reactive protein, liver enzymes, and kidney function. Conclusion: While percentage weight loss and glycemic control were similar between genders, men experienced greater reductions in percentage body fat, visceral fat, and triglycerides compared to women. These findings suggest that gender-specific differences in body composition and lipid response may exist, warranting further investigation to optimize individualized treatment strategies. Disclosure F. Trabzounly: None. M. Al-Badri: None. M. Fallaha: None. J. Jacob: None. A. Mottalib: Consultant; Current; American Diabetes Association. O. Hamdy: Research Support; Current; Novo Nordisk. Consultant; Current; Abbott. Research Support; Current; Eli Lilly and Company.