Key result
Lipoprotein transport gene mutations underlie common lipid abnormalities linked to coronary heart disease risk.
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There is a close association between lipoprotein abnormalities and coronary heart disease susceptibility. Since 1982, the genes for the lipoprotein transport proteins have been isolated and at least partially characterized. Mutations in these genes are now being defined that underlie the common abnormalities found in heart attack victims. This review presents our current state of knowledge on this subject.
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Jan L. Breslow (1991) conducted a review in Coronary heart disease and lipoprotein abnormalities. Lipoprotein transport gene mutations was evaluated on Coronary heart disease susceptibility. Mutations in lipoprotein transport protein genes isolated since 1982 underlie common lipoprotein abnormalities closely associated with coronary heart disease susceptibility.
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