October 3, 2026Annual Review of Medicine
Treatment of Tricuspid Valve Disease
Key result
Transcatheter tricuspid interventions safely reduce regurgitation and HF hospitalizations while improving short-term quality of life.
Why the study?
Tricuspid valve disease is increasing in prevalence and associated with high morbidity and mortality, yet traditional surgical options are often unsuitable due to patient comorbidities, prompting exploration of transcatheter interventions.
Do transcatheter interventions improve outcomes in patients with severe tricuspid regurgitation?
Comparison
Transcatheter edge-to-edge repair and transcatheter tricuspid valve replacement vs traditional medical therapy
Design
Pivotal trials evaluating transcatheter interventions
Follow-up
Short term
Authors
Discussion
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Implication
Transcatheter options may reduce risk for high-comorbidity patients with severe tricuspid regurgitation; leaves open need for randomized outcome trials.
Key Points
- To review the evolving management strategies for tricuspid valve disease, focusing on the clinical transition from medical therapy and high-risk surgery to transcatheter therapies.
- Narrative synthesis of recent clinical trials and literature evaluating treatment modalities for tricuspid regurgitation.
- Assessment of clinical efficacy and safety outcomes for transcatheter edge-to-edge repair (TEER) and transcatheter tricuspid valve replacement (TTVR).
- Transcatheter edge-to-edge repair and valve replacement safely achieve robust reductions in tricuspid regurgitation severity.
- Therapies demonstrate significant reductions in heart failure hospitalizations and marked short-term improvements in patient-reported quality of life.
- Device durability and value-based cost-effectiveness require further long-term investigation.
Structured PICO
Do transcatheter interventions improve outcomes in patients with severe tricuspid regurgitation?
P
Population
Patients with severe tricuspid regurgitation
I
Intervention
Transcatheter edge-to-edge repair and transcatheter tricuspid valve replacement
C
Comparator
Traditional surgical tricuspid valve replacement/repair or medical therapy
Transcatheter interventions represent a major paradigm shift for treating severe tricuspid regurgitation, offering safe and effective alternatives to high-risk surgery or medical therapy alone.
Limitations
- Durability of transcatheter devices is not yet established
- Cost-effectiveness within a value-based healthcare framework needs evaluation
- Durability of devices not yet established
Cite This Study
Pliakos et al. (2026) conducted a review in Tricuspid valve disease. Transcatheter interventions (edge-to-edge repair and valve replacement) vs. Medical therapy or traditional surgery (historical) was evaluated. Transcatheter edge-to-edge repair and valve replacement safely reduce tricuspid regurgitation and heart failure hospitalizations, and improve short-term quality of life.