Key result
Type 1 diabetes in adolescents was associated with decreased flow-mediated dilation compared to healthy controls (P=0.023), which inversely correlated with mean second-year HbA1c (r=-0.426, P=0.02).
Why the study?
Is glycemic control associated with endothelial dysfunction in adolescents with early Type 1 Diabetes Mellitus?
Population
57 adolescents with Type 1 Diabetes Mellitus (T1DM) and 10 healthy age-matched controls
Design
Cross-sectional
Authors
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Suggests early vascular effects of glycemic control in adolescent T1DM; leaves open whether intervention alters outcomes.
Cross-Sectional (n=67)
No
Is glycemic control associated with endothelial dysfunction in adolescents with early Type 1 Diabetes Mellitus?
p-value: p=0.023
Endothelial dysfunction is common in adolescents with early Type 1 Diabetes and correlates with prior glycemic control, supporting the metabolic memory hypothesis.
Cé et al. (2011) conducted a cross-sectional in Type 1 Diabetes (n=67). Type 1 Diabetes vs. Healthy age-matched controls was evaluated on Endothelial function evaluated by flow-mediated dilation (FMD) (p=0.023). Type 1 diabetes in adolescents was associated with decreased flow-mediated dilation compared to healthy controls (P=0.023), which inversely correlated with mean second-year HbA1c (r=-0.426, P=0.02).
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