Why the study?
Does heavy cigarette smoking increase left ventricular mass through elevated ambulatory blood pressure in patients with essential hypertension?
Population
575 patients with essential hypertension, including 115 heavy smokers and 460 non-smokers, matched 1:4 by…
Comparison
Heavy cigarette smoking (≥ 20 cigarettes/day) vs Non-smokers with essential hypertension, matched…
Design
Case-control
Authors
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Daytime ambulatory BP may mediate smoking-related LV mass increases missed by clinic readings; supports mechanism but leaves open causal inference.
Does heavy cigarette smoking increase left ventricular mass through elevated ambulatory blood pressure in patients with essential hypertension?
Heavy smoking increases left ventricular mass in essential hypertension primarily through an elevation in daytime ambulatory blood pressure that is not detected by standard clinic measurements.
Verdecchia et al. (1995) studied this question.
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