Population
Cell cultures infected with rhinovirus strains 1A and 13, and mice
Comparison
Liposome-incorporated enviroxime administered by… vs Free enviroxime
Design
Preclinical
Follow-up
20 min (for aerosol delivery assessment)
Authors
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May enable safer aerosol enviroxime delivery; leaves open translation to human rhinovirus therapy.
Incorporating enviroxime into liposomes significantly reduces its cellular toxicity and enables successful aerosol delivery to the respiratory tract in a murine model.
Wyde et al. (1988) studied this question.
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