April 1, 1985Antimicrobial Agents and ChemotherapyOpen Access

Comparative studies on the modes of action of the antirhinovirus agents Ro 09-0410, Ro 09-0179, RMI-15,731, 4',6-dichloroflavan, and enviroxime

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Population

Human rhinovirus serotypes and sublines

Design

Preclinical

Authors

YNYasuyuki NinomiyaChiba University MAM. Aoyama IUI Umeda

Discussion

Member takes

Implication

Distinguishes capsid-binding mechanisms among rhinovirus antivirals in animal models; leaves open translation to human efficacy or therapy.

Structured PICO

Population

Human rhinovirus serotypes and sublines

Intervention

Antirhinovirus agents (Ro 09-0410, Ro 09-0179, RMI-15,731, 4',6-dichloroflavan, and enviroxime)

Outcome

Mode of action (viral inactivation, binding to viral capsid protein, and cross-resistance)surrogate

Ro 09-0410, 4',6-dichloroflavan, and RMI-15,731 share a common mechanism of action by binding to the viral capsid protein of human rhinovirus, distinct from Ro 09-0179 and enviroxime.

Cite This Study

Ninomiya et al. (1985) studied this question.

synapsesocial.com/papers/6a87d1933bdf89560ead32f5 https://doi.org/10.1128/aac.27.4.595

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Implication

Distinguishes capsid-binding mechanisms among rhinovirus antivirals in animal models; leaves open translation to human efficacy or therapy.

Comparative studies on the modes of action of the antirhinovirus agents Ro 09-0410, Ro 09-0179, RMI-15,731, 4',6-dichloroflavan, and enviroxime

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparative studies on the modes of action of the antirhinovirus agents Ro 09-0410, Ro 09-0179, RMI-15,731, 4',6-dichloroflavan, and enviroxime

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider