Key result
Changing the timing of aspirin administration from morning to evening did not significantly alter mean 24-hour systolic blood pressure (128.3 vs. 128.3 mmHg) in treated hypertensive patients.
Why the study?
Does evening administration of aspirin reduce 24-hour systolic blood pressure compared to morning administration in treated hypertensive patients?
RCT (n=75)
Cross-over
Does evening administration of aspirin reduce 24-hour systolic blood pressure compared to morning administration in treated hypertensive patients?
Absolute Event Rate: 128.3% vs 128.3%
Changing the timing of aspirin administration from morning to evening does not significantly affect 24-hour blood pressure in treated hypertensive patients.
Evening aspirin offers no BP-lowering advantage over morning dosing; confirms lack of chronotherapeutic effect on 24-hour SBP.
BACKGROUND AND DESIGN: The effects of aspirin on blood pressure (BP) are controversial and a chronopharmacological effect of aspirin on 24-hour BP was reported recently in otherwise untreated hypertensive patients. The study was designed to test the timing effect of aspirin dosing on 24-hour BP in treated hypertensive patients routinely taking aspirin for cardiovascular prevention. METHOD AND RESULTS: Seventy-five patients were randomized into two groups. One group was to receive aspirin in the evening then in the morning for 1 month and the other group in the morning then in the evening, following a cross-over design. The principal assessment criterion was 24-hour systolic BP (SBP) measured by 24-hour ambulatory BP monitoring (ABPM). Patients were aged 65 ± 9 years and had been hypertensive for 12 ± 10 years. They were all taking a mean of 2.8 antihypertensive drugs and did not modify their treatment throughout the study. Of the included subjects, 70% were men and 33% were diabetics. Mean 24-hour SBP values were clinically equivalent and were not statistically different, depending on whether the aspirin was taking in the morning or evening (128.3 ± 1.4 vs. 128.3 ± 1.4 mmHg, respectively). Neither was there any significant difference in diurnal and nocturnal SBP or in 24-hour, diurnal, and nocturnal diastolic BP (DBP). CONCLUSION: It does not appear useful to advise patients with long-standing hypertension to modify timing of aspirin intake in order to reduce BP values.
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Dimitrov et al. (2011) conducted an RCT in Hypertension (n=75). Aspirin administration in the evening vs. Aspirin administration in the morning was evaluated on 24-hour systolic BP (SBP) measured by 24-hour ambulatory BP monitoring (ABPM). Changing the timing of aspirin administration from morning to evening did not significantly alter mean 24-hour systolic blood pressure (128.3 vs. 128.3 mmHg) in treated hypertensive patients.
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