Key result
Inter-ankle systolic blood pressure difference is linked to subclinical hypertensive renal damage.
Why the study?
It was unknown whether inter-ankle systolic blood pressure difference is associated with different stages of hypertensive renal damage.
Is inter-ankle systolic blood pressure difference associated with microalbuminuria in non-diabetic hypertensive patients?
Cross-Sectional (n=2,489)
Yes
Is inter-ankle systolic blood pressure difference associated with microalbuminuria in non-diabetic hypertensive patients?
Inter-ankle systolic blood pressure difference can serve as a useful clinical marker to identify microalbuminuria and aid in risk stratification for non-diabetic hypertensive patients.
This cross-sectional study aimed to analyze whether inter-ankle systolic blood pressure difference (sIAND) was associated with different stages of hypertensive renal damage. 1,658 and 831 nondiabetic hypertensive patients were included from two cohorts. The hypertensive renal damage was reflected by urinary albumin-to-creatinine ratio (UACR), Cystatin C, and estimated glomerular filtration rate. Logistic regression results showed that sIAND was only associated with subclinical hypertensive renal damage reflected by microalbuminuria (UACR > 30 mg/g) independently. Receiver operating characteristic curves indicated sIAND can identify microalbuminuria more effectively. sIAND can aid in identifying microalbuminuria to provide useful clues for risk stratification and clinical management.
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Shi et al. (2026) conducted a cross-sectional in Non-diabetic hypertension (n=2,489). Inter-ankle systolic blood pressure difference (sIAND) was evaluated on Subclinical hypertensive renal damage reflected by microalbuminuria (UACR > 30 mg/g). Inter-ankle systolic blood pressure difference (sIAND) was independently associated with subclinical hypertensive renal damage reflected by microalbuminuria (UACR > 30 mg/g).
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