March 1, 1997Diabetes Care
Elevated Ambulatory Blood Pressure in Microalbuminuric IDDM Patients Is Inversely Associated With Renal Plasma Flow: A compensatory mechanism?
Key result
Microalbuminuria in male IDDM patients is linked to ~7 mmHg higher daytime systolic AMBP.
- P<0.05
- n=38
Population
38 male patients with insulin-dependent diabetes mellitus, including 19 with slight microalbuminuria and 19…
Design
Cross-sectional
Authors
Discussion
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Implication
Associated daytime systolic BP elevation in microalbuminuric male IDDM may indicate early renal flow reduction; leaves open causal role and need for prospective studies.
Study Design
Type
Observational (n=38)
Structured PICO
P
Population
38 male patients (mean age 33) with IDDM, divided into microalbuminuric and normoalbuminuric groups, to evaluate the relationship between renal function, ambulatory blood pressure, and glycemic control.
C
Comparator
Normoalbuminuric IDDM patients
O
Outcome
Relationship between renal function (glomerular filtration rate and effective renal plasma flow), ambulatory blood pressure (AMBP), and glycemic controlsurrogate
Main Result
Absolute Event Rate: 132% vs 125%
p-value: p=<0.05
In male IDDM patients with microalbuminuria, elevated ambulatory blood pressure is strongly inversely associated with renal plasma flow, suggesting a potential early compensatory or maladaptive mechanism.
Cite This Study
Poulsen et al. (1997) conducted an observational in Insulin-Dependent Diabetes Mellitus (IDDM) (n=38). Microalbuminuria vs. Normoalbuminuria was evaluated on Daytime systolic AMBP (p=<0.05). Microalbuminuria in male IDDM patients was associated with higher daytime systolic AMBP (132 vs 125 mmHg, P<0.05), which inversely correlated with renal plasma flow (r=-0.77, P<0.005).