Key result
Glomerular hyperfiltration in normotensive, normoalbuminuric IDDM patients was associated with higher mean nocturnal diastolic blood pressure (70.4 vs 65.1 mmHg, P=0.04) and a blunted nocturnal decrease.
Why the study?
Is glomerular hyperfiltration associated with abnormal blood pressure patterns in normotensive normoalbuminuric IDDM patients?
Population
58 individuals, comprising 38 normotensive normoalbuminuric IDDM patients and 20 normal individuals matched…
Design
Cross-sectional
Authors
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May flag early hemodynamic risk in IDDM; leaves open predictive value for nephropathy progression.
Cross-Sectional (n=58)
Is glomerular hyperfiltration associated with abnormal blood pressure patterns in normotensive normoalbuminuric IDDM patients?
Absolute Event Rate: 70.4% vs 65.1%
p-value: p=0.04
Glomerular hyperfiltration in normotensive, normoalbuminuric IDDM patients is associated with blunted nocturnal dipping of diastolic blood pressure, indicating early hemodynamic alterations.
Pecis et al. (1997) conducted a cross-sectional in Insulin-Dependent Diabetes Mellitus (IDDM) (n=58). Glomerular hyperfiltration vs. Normofiltering IDDM patients and normal individuals was evaluated on Mean nocturnal diastolic blood pressure (p=0.04). Glomerular hyperfiltration in normotensive, normoalbuminuric IDDM patients was associated with higher mean nocturnal diastolic blood pressure (70.4 vs 65.1 mmHg, P=0.04) and a blunted nocturnal decrease.
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